ABSTRACT
The COVID-19 is spreading rapidly over the globe disease . A deadly global pandemic of Coronavirus sickness (COVID-19) has caused significant morbidity and mortality in a number of locations. Oxidative stress appears to play a role in COVID-19. The goal of this case-control study was to compare the levels of total antioxidant capacity (TAC), total oxidant status (TOS), and lipid peroxidation products like malondialdehyde (MDA) in the serum of COVID-19 infection patients to a healthy control group, with a scientific interpretation of the results. The data was gathered from (90) participants who were classified into two categories: patients and controls. The CUPRAC procedure evaluates A spectrophotometric reader was used to determine the total oxidant status (TOS). With a p-value of 0.05, the results revealed that there were significant variations in TOS levels between the COVID -19 and control groups (0.009). TAC levels differed significantly between the patient and control groups, with a p-value of (0.012), while TAC levels in the patient group dropped. (1.24+/-0.15), compared to (1.55+/-0.31) in the control group;moreover, oxidative stress is higher in covid-19, with MDA levels of (6.45+/-1.14), compared to (3.22+/-0.69) in the control group, with a significant p-value (0.002). Conclusion(s): Based on the data, it seems that levels of (MDA) are higher in the COVID-19 group than in the control group due to Infection with a virus and a storm of the immune system In addition to acting as an anti-inflammatory mediator, (MDA) is a biomarker for lipid peroxidation, and an increase in free radicals causes oxidative stress, resulting in an increase in (MDA) levels. (TAC) levels were also lower in patients than in the control group, and our findings revealed that patients had higher (TOS) levels than the control group. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.
ABSTRACT
Aims of study: The purpose of this study is to compare the levels of plasmin, inducible nitric oxide, and nitric oxide in COVID-19 infection patients to a healthy control group, with a scientific interpretation of the predicted results. Methods: Data was collected from ninety people, divided into two groups: patients and controls, and a demographic study was conducted, which included age, gender, oxygen saturation, and BMI, with diabetes and asthma eliminated. The plasmin and inducible nitric oxide levels are estimated using the enzyme-linked immune sorbent assay (ELISA) technique, and nitric oxide is measured using a spectrophotometer. Results: Patients with COVID-19 showed a substantial rise in the values of plasmin and inducible nitric oxide synthase enzyme, as well as a decrease in the value of nitric oxide, when compared to healthy controls. © 2022 International Journal of Health Sciences. All rights reserved.
ABSTRACT
Vitamin D is fat soluble vitamin synthesis from isoprenoid units by condensation process in vivo when exposure to sun light (weak UV source). The main function of vitamin D is maintenance on calcium hemostasis, beside this function has important role as a protection factor from many disease such as autoimmune diseases and cancer. There are several suggestions to support the immunity such as intake vitamin D that has the ability to reduce the risk of respiratory tract infections, such as epidemiology of influenza and COVID-19. Vitamin D can reduce the risk of COVID-19 infection through the mechanisms including lowering replication of virus by induction of cathelicidins and reduced the inflammatory cytokines that produced from the lining cells of lungs which lead to pneumonia and lung fibrosis due to autoimmune diseases as well as increase the concentrations of anti-inflammatory cytokines.